Dr. Holler serves as Professor of Neurosurgery at Cedars-Sinai Medical Center and Professor of Biochemistry at the University of Regensburg, Germany.

Dr. Holler’s internationaly renowned research focuses on design, synthesis and characterization of novel nanoscale drug delivery systems based on polymalic acid. These “nano drugs” are single macromolecules, which are applicable in personalized medicine especially cancer treatment. They provide targeting of tumor markers and an array of prodrugs which are activated at the site of targeted cells in response of specific cellular stimuli. The nanomedicine was established in preclinical models of solid breast and brain tumors and for brain metastases and is prepared for translation into clinics. After appropriate modifications, the nanomaterial was transformed into reagents for differential diagnosis by MRI of solid and metastatic brain tumors